Christina Applegate says she lies in bed ‘screaming’ due to ‘sharp pains’ from MS

Christina Applegate said she lies in bed “screaming” due to the “sharp pains” from her multiple sclerosis (MS).

On the Tuesday episode of her “MeSsy” podcast, the “Married… with Children” alum and her co-host, Jamie-Lynn Sigler, who also has MS, chatted with guest Rory Kandel, a bakery owner who was diagnosed with the same chronic disease.

“I lay in bed screaming — like, the sharp pains, the ache, that squeezing,” Applegate, 52, confessed during the show.

Kandel said she sometimes feels like she has “knives in [her] stomach,” adding, “I’ll be laying in bed, and I wake up, and I physically can’t turn from side to side.”

“Do you feel like that?” the baker asked the “Dead to Me” actress, who replied: “Every single day of my life.”

“I can’t even pick up my phone sometimes because now it’s traveled into my hands, so I’ll, like, try to go get my phone or get my remote to turn on the TV or sometimes, I can’t even hold them. I can’t open bottles now,” Applegate added.

The “Anchorman: The Legend of Ron Burgundy” star said there were days when her MS, a chronic disease that damages the central nervous system by attacking the protective coating around nerve fibers, was so painful she would “just lay in bed all the time.’

Applegate would also compare the floor to lava due to how much pain she felt when she tried to get out of bed.

“I put my feet on the ground and they’re hurting, like, extraordinarily bad to the touch,” she shared.

“I was like, ‘Yep. Gonna get back in my bed and pee in my diaper because I don’t feel like walking all the way to the damn bathroom,'” she quipped.

“I actually don’t lay here and pee in my bed diaper. That’s just a joke. But it’s like it’s so freaking painful and so hard and so awkward.” 

Applegate was diagnosed with MS in early 2021.

The mom of one has been candid about how MS has affected her health and career.

In 2022, Applegate revealed “Dead to Me” would probably be her last acting gig due to her declining health.

And in March, she revealed that she now has to wear diapers and has 30 lesions on her brain.