49ers Lose Another RB to Injury Ahead of Dolphins Matchup

The ongoing epidemic in the San Fransisco 49ers' backfield just spread a bit further.

49ers running back Isaac Guerendo San Fransisco is officially listed as out for Sunday's game against the Miami Dolphins, as per ESPN's Adam Schefter.

"After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday's game vs. Miami. Guerendo is dealing with a hamstring injury and is unlikely to play, per source," Schefter posted on X.

Guerendo hurt his hamstring in his first career NFL start in Week 14 against the Chicago Bears when he was tackled by a couple of defenders and landed at the bottom of a pile.

After exiting the game with a questionable designation, Guerendo returned for the 49ers' 12-6 loss against the Los Angeles Rams on short rest.

SANTA CLARA, CALIFORNIA - NOVEMBER 17: Isaac Guerendo #31 of the San Francisco 49ers warms up before a game against the Seattle Seahawks at Levi's Stadium on November 17, 2024 in Santa Clara, California. The... Lachlan Cunningham/Getty Images

This story is in the process of being updated.